A Comprehensive Review on Cubosome: A Novel ...

A Comprehensive Review on Cubosome: A Novel Versatile Nanocarrier

Author Name : Aashish Singh ,Dr. Kamlesh Dashora , Dr. Tanu Bhargav , Dr. Dharmesh Sisodiya , Dr. Praveen Khirwadkar , Anju Tomar

ABSTRACT Cubosome a self -assembled liquid nanocrystal is a novel nanodrug delivery carrier of cubic shape and amphiphilic in nature. Cubosome gets a center of attention due to its unique architecture and entrapment capability of wide range of drug including both hydrophilic and lipophilic drugs. Cubosome encompasses of curved lipid bilayer arranged in three- dimensional structure that resembles with honeycomb. Between the lipid bilayer there exist aqueous channel which have a large interfacial area. The presence of both lipid and aqueous phase makes cubosome versatile in case of drug entrapment, but about 60% of outer surface of cubosome contacts with water so it is most suitable for hydrophilic drugs. The preparation of liquid crystal is simple and can be prepared by aqueous phase by ultrasonication.Cubosome are formulated simply by mixing lipids with water.Generally, Glycerylmonooleate lipid is mixed with water which is biocompatible with body tissue and pharmaceutical purposes. There are two main approaches of cubosome preparation (1) Top-down approach (2) Bottom-up approach. In top-down approach, melted lipid is added with aqueous phase and by sonication or homogenization liquid cubic crystal is prepared While in bottom-up approach crystallization occurred from a precursor.Cubosome have several advantages like Non-allergic, Non-irritant, Thermodynamic stability,Physicochemical stability and larger entrapment efficiency. Cubosome have stable thermodynamic state and cubosomal dispersions have mucoadhesive and biodegradable property. Drug candidates like cosmetics and protein can also be formulated in cubosome.Cubosome acts as a carrier for drug of various routes like – Oral route, Nasal route, Intravenous route, Topical route and also through Ophthalmic route. By transdermal or topical preparation cubosome mainly formulated to act on increased penetration and bioavailability. In recent advancement cubosome are also used in Diabetes and Anticancer preparation. Due to versatile structure and loading capacity for drug cubosome can be widely used as controlled release formulation as well as in sustained release formulation. It can also be used in drugs of different natures, Purposes and property.

Key Words-Cubosome, Top-down approach, Bottom- up approach, Glyceryl monooleate