Antibiotic Resistance in Bacterial Infections

Antibiotic Resistance in Bacterial Infections

Author Name : Bhushan Chavan, Ms. Shital Khandagale, Dr. Gajanan Sanap

DOI: https://doi.org/10.56025/IJARESM.2024.121224041

ABSTRACT Antibiotics have made it feasible to deal with bacterial infections inclusive of meningitis and bacteraemia that, previous to their introduction, have been untreatable and therefore fatal. Unfortunately, in current a long time overuse and misuse of antibiotics in addition to social and monetary elements have improved the unfold of antibiotic-resistant micro organism, making drug remedy ineffective. Currently, at the least 700,000 human beings global die every yr because of antimicrobial resistance (AMR). Without new and higher treatments, the World Health Organization (WHO) predicts that this wide variety should upward push to ten million through 2050, highlighting a fitness situation now no longer of secondary importance. In February 2017, in mild of growing antibiotic resistance, the WHO posted a listing of pathogens that consists of the pathogens special through the acronym ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) to which have been given the highest “precedence status” on account that they constitute the extraordinary hazard to humans. Understanding the resistance mechanisms of those micro organism is a key step withinside the improvement of latest antimicrobial tablets to address drug-resistant micro organism. In this review, each the mode of motion and the mechanisms of resistance of usually used antimicrobials might be examined. It additionally discusses the present day kingdom of AMR withinside the maximum important resistant micro organism as decided through the WHO`s international precedence pathogens listing.