Effect of Manganese on the Haemopoietic organ...

Effect of Manganese on the Haemopoietic organs of Garra gotyla gotyla

Author Name : Jyoti Sharma, Gurpreet Kour

ABSTRACT

In the present study, an attempt has been made to evaluate the various histopathological alterations in haemopoietic organs viz. liver, head kidney and spleen of Garra gotyla gotyla following an exposure to sublethal concentration of Manganese of 0.64mg/l for an experimental duration of 9 weeks. Various abnormalities observed in the liver were necrosis of hepatocytes, distension of sinusoids, vacuolation of hepatocytes, increase in melanomacrophage centres (MMCs) which resulted in the loss of normal cellular architecture and functioning of liver. Necrosis, vacuolation, deposition of haemosiderin pigments and proliferation of melanomacrophage centres (MMCs) were the conspicuous changes observed in the splenic tissue. Head kidney too demonstrates various degenerative changes which include necrosis of haemopoietic tissue, vacuolation of renal tubules and reduction in haemopoietic tissue.

Key Words: Manganese, Garra gotyla gotyla, Haemosiderin, Melanomacrophage centres.