Formulation Development and In-Vitro Evaluati...

Formulation Development and In-Vitro Evaluation of Deflazacort Fast Dissolving Tablets

Author Name : G. Srujana, Jimidi Bhaska

ABSTRACT The aim of the current research to develop fast dissolving tablets (FDTs) of Deflazacort by direct compression method. Deflazacort goes under Biopharmaceutical Classification System(BCS) II drug i.e., less dissolvability and high vulnerability which brings about less bioavailability of drug. The target of the existing work is expected to develop FDTs by utilizing superdisintegrants. Precompression and postcompression parameters of FDTs were evaluated. Out of 6 formulations DF6 containing sodium starch glycolate as disintegrant shows highest drug release in 15min, which is considered as optimized formulation. Accelerated stability study indicates no variation in parameters.