Identification, Extraction of Brassica Olerac...

Identification, Extraction of Brassica Oleraceae Using Behavioural Despair Test, Tail Suspensi and Its Depression Activity using Albino Rats

Author Name : D. Venkata Satya Sarat Chandra, Vinjavarapu. L. Anusha, Monica Sharon Patchala, K. Ananda Babu, Dr. G. Kiran

ABSTRACT

Depression is a widespread psychiatric disorder affecting around 5% of the population. Furthermore, it is difficult to predict which patient will respond to any given treatment. In the traditional systems of medicine, many plants and formulations have been used to treat depression for thousands of years. Brassica oleraceae contains tannic acid as its main ingredient and this compound has been shown to have non-selective mono-amine oxidase activity. Therefore, the present study was undertaken to evaluate the antidepressant potential of acute and chronic administration of Brassica oleraceae in behavioural despair test and tail suspension test (TST). Inbred adult male albino rats weighing 155-180g were used in the study. standard drug (imipramine) and test drug (Brassica oleraceae) were suspended in 1% gum acacia. The vehicle (10ml/kg, p.o), imipramine (20mg/kg, p.o) and eo (100mg/kg, 200mg/kg, 400mg/kg, p.o. respectively) were administered 1hour prior to acute study. in chronic study, all drugs were given for 10 days and the last dose was given 1hour before the experiment. Duration of immobility was noted in both the models. in our study, both imipramine and brassica oleraceae significantly reduced the duration of immobility in both experimental models as compared to the animals in the control group. The antidepressant activity of brassica oleraceae was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of brassica oleraceae as an adjuvant in the treatment of depression.

Keywords: Behavioural despair test, tail suspension test, brassica oleraceae, Depression