In Vitro Antioxidant Activity and Acute Oral ...

In Vitro Antioxidant Activity and Acute Oral Toxicity Study of Polyherbal Formulation (Alangium Salviifolium & Clitoria Terntea) in Mice

Author Name : Mr. Choudhary K. Naresh*, Mr. Kedar Gangadhar, Mrs. Swati U Kolhe, Dr. Sachin Themburne

ABSTRACT Alangiumsalvifolium and Clitoriatrentea are the medicinal plants which are reported that they can be used to treat brain related disorders for their nootropic activity. Alangiumsalvifolium (Linn. F) Wang. is a little deciduous tree or bush, which develop in the wild all through the hotter regions of the India. It has a place with the family Alangiaceae. It is utilized as diuretic, astringent, sharp, anthelminthic, laxative, emetic, against protozoal, hypoglycemic movement, hostile to diabetic and for anti-ulcer action. Clitoriaternatea, ordinarily known as Shankpushpi, is generally utilized in the conventional Indian Ayurvedic medication as a mind tonic and is accepted to advance memory and insight. The purpose of this study was to test the in-vitro antioxidant activity and acute oral toxicity of the extracts of the seeds obtained from these both plants. Acute oral toxicity study of ethanolic extract of the seeds obtained from Alangiumsalvifolium and Clitoriaterntea was performed. The extract was prepared in the ratio of 1:1 of both plant seeds powder. Acute toxicity studies were adopted from OECD guidelines 423. The animals were orally administered a single dose of 250, 500, 1000 and 2000 mg/kg body weight. Indications of mortality and toxicity were noted after 1hr, 4hr, and 24hr of administration of the extract for 14 days. The highest dose administered was (2000mg/kg body weight).