Innovative Methods of Pharmacological Activit...

Innovative Methods of Pharmacological Activities of Two Indian Medicinal Plants: Wrightia Tinctoria and Capparis Zeylanica

Author Name : Manimegalai.S, Dr. S. Venkatesh

ABSTRACT

The current research focuses at assess the antipyretic, analgesic and anti-inflammatory properties of methanolic extract of the bark, leaves and stem of Wrightia Tinctoria and Capparis Zeylanica. The AEWT and AECZ extract conferred a remarkable (***p > 0.001) dose dependent increases reaction time in writhing method and showed inhibition of 63.1% and 57.1% separately at the doses of 400 mg/kg body weight while standard drug showed (P > 0.001) inhibition of 69.23%. In tail immersion method, AEWT and AECZ showed maximum time of tail retention at 30 minutes in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62 sec. The AEWT and AECZ extract also appeared promising anti-inflammatory effect as denoted by statistically remarkable inhibition of paw volume by 32.48% and 26.75% respectively at the dose of 400 mg/kg body weight while the value at the dose of 200 mg/kg body weight were linear to higher dose at the 3^rd hour of analysis. On the other hand, Standard indomethacin inhibited 40.13% of swelling (***P > 0.001). In Cotton-pellet granuloma method, AEWT and AECZ extract at the dose of 400 mg/kg body weight showed inhibition of swelling of 34.7% and 29.1% respectively while standard drug showed (P > 0.001) inhibition of 63.22%. Intraperitoneal administration of AEWT and AECZ showed dose dependent decrease in body temperature in brewer’s yeast induced hyperthermia in rats at both doses. However, AEWT remarkably decreased body temperature (***p > 0.001) at 400 mg/kg compared to control. The proposed work that the methanolic extract of Wrightia Tinctoria and Capparis Zeylanica possesses dose dependent pharmacological action which helps its therapeutic use in folk medicine possibly mediated through the inhibition or choke of release prostaglandin and/or actions of vasoactive substances such as kinins, serotonin and histamine.

Keywords: Wrightia Tinctoria, Capparis Zeylanica, Antipyretic, Analgesic, Anti-inflammatory.

ABSTRACT

The current research focuses at assess the antipyretic, analgesic and anti-inflammatory properties of methanolic extract of the bark, leaves and stem of Wrightia Tinctoria and Capparis Zeylanica. The AEWT and AECZ extract conferred a remarkable (***p > 0.001) dose dependent increases reaction time in writhing method and showed inhibition of 63.1% and 57.1% separately at the doses of 400 mg/kg body weight while standard drug showed (P > 0.001) inhibition of 69.23%. In tail immersion method, AEWT and AECZ showed maximum time of tail retention at 30 minutes in hot water i.e. 6.93 sec and 6.54 sec respectively at highest doses of 400 mg/kg body weight than lower dose while standard pentazocine showed reaction time of 7.62 sec. The AEWT and AECZ extract also appeared promising anti-inflammatory effect as denoted by statistically remarkable inhibition of paw volume by 32.48% and 26.75% respectively at the dose of 400 mg/kg body weight while the value at the dose of 200 mg/kg body weight were linear to higher dose at the 3^rd hour of analysis. On the other hand, Standard indomethacin inhibited 40.13% of swelling (***P > 0.001). In Cotton-pellet granuloma method, AEWT and AECZ extract at the dose of 400 mg/kg body weight showed inhibition of swelling of 34.7% and 29.1% respectively while standard drug showed (P > 0.001) inhibition of 63.22%. Intraperitoneal administration of AEWT and AECZ showed dose dependent decrease in body temperature in brewer’s yeast induced hyperthermia in rats at both doses. However, AEWT remarkably decreased body temperature (***p > 0.001) at 400 mg/kg compared to control. The proposed work that the methanolic extract of Wrightia Tinctoria and Capparis Zeylanica possesses dose dependent pharmacological action which helps its therapeutic use in folk medicine possibly mediated through the inhibition or choke of release prostaglandin and/or actions of vasoactive substances such as kinins, serotonin and histamine.

Keywords: Wrightia Tinctoria, Capparis Zeylanica, Antipyretic, Analgesic, Anti-inflammatory.