Research on:- Synthesis and evaluation of phe...

Research on:- Synthesis and evaluation of phenothiazine derivative for Antidepressant Activity

Author Name : Yogita Kirdant, Borude Vaishnavi, Swagati S.A

ABSTRACT Phenothiazines are widely used in various medical fields, particularly in psychopharmacology. These substances have the ability to effectively block dopamine, histamine, serotonin, acetylcholine, and a-adrenergic receptors, resulting in a wide range of effects and side effects. In addition to their antipsychotic properties, phenothiazines also exhibit significant antimicrobial effects by enhancing the bactericidal function of macrophages and inhibiting efflux pumps. They can also eliminate bacterial resistance plasmids and disrupt bacteria through their membrane-destabilising effect. Furthermore, they have been found to have antiviral, antiprotozoal, antifungal, and antiprion activities. Clinical trials have also shown that phenothiazines can destroy cancer cells and make them more susceptible to chemotherapy. Additionally, they have been reported to have antiangiogenesis and anti-cancer stem cell activities, suggesting potential applications as adjuvants in the treatment of infections and tumours. Finally, phenothiazines may also be effective in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.