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Synthesis and Biological Screening of Some Novel Pyridin-2(1H)-One Derivative
Author Name : K. J. Suthar, V.T. Chudasama, M. K. Patel, B. S. Rajpurohit
ABSTRACT Acetone dicarboxylic acid prepared from reaction of citric acid with conc. H2SO4 .4-(4-chlorophenyl) thiazol-2- amine is prepared by reaction of Thiourea and I2 were triturated and reflux with p-chloroacetophenone. Now, 1-(4- (4-Chlorophenylthiazol-2-yl)-4-(4-Methoxyphenyl)Pyridine-2,6(1H,3H)- dione is prepared by refluxing of 4-(4- chlorophenyl) thiazol-2-amine and 3-(4-Methoxy phenyl) pentanedioic acid in methanol. 5,6-dichloro-1-(4-(4- Chlorophenyl)thiazol-2-yl)-4-(4-Methoxyphenyl) pyridine- 2(1H)-one is prepared by reaction of 1-(4-(4- Chlorophenylthiazol-2-yl)-4-(4-Methoxyphenyl) Pyridine-2,6 (1H,3H)-dioneand phosphorous oxychloride.1-(4-(4- Chlorophenyl)thiazol-2-yl)-4-(4-methoxyphenyl)-5,6-bis(o-/m-/p-Toluidino) pyridine-2(1H)-One is prepared by reaction of 5,6-dichloro-1-(4-(4-Chlorophenyl)thiazol-2-yl)-4-(4-methoxyphenyl) pyridine-2(1H)-One and o-,m-,pToluidine. All the title compounds characterised on the basis of their MASS, 1H NMR spectroscopic data analysis